NEODOSE

INDICATIONS

Skeletal muscle relaxation/paralysis in infants requiring mechanical ventilation. Proposed desirable effects are improved oxygenation/ ventilation, reduced barotrauma, and reduced fluctuations in cerebral blood flow.

ADVERSE EFFECTS

Hypoxemia may occur because of inadequate mechanical ventilation and deterioration in pulmonary mechanics. When used alone, cardiovascular side effects are minimal; however, decreases in heart rate and blood pressure have been observed when used concurrently with narcotics.

ADMINISTRATION

• Must be accompanied by adequate analgesia and/or sedation.
• Administer IV push over 5 to 10 seconds. For continuous IV infusion, may dilute in compatible diluent to a concentration of 0.1 to 0.2 mg/mL, or infuse undiluted at a concentration of 1 mg/mL.
• The final concentration of each vial is 100 international units/mL when each vial is reconstituted with 1.25 mL of diluent.

BLACK BOX WARNING

BLACK BOX WARNING According to the manufacturer’s , vecuronium should be administered by adequately trained individuals familiar with its actions, characteristics, and hazards.

MONITORING

Monitor vital signs frequently, blood pressure continuously. Use some form of eye lubrication.