Infant Data
Postmenstrual Age(PMA) = gestational age plus postnatal age.
Results
INDICATIONS
Timentin injection is no longer marketed in the United States. Treatment of non-CNS infections, caused by susceptible β-lactamase producing bacteria, including many strains of E. coli, Enterobacter, Klebsiella, Haemophilus influenzae, Proteus mirabilis, Pseudomonas spp., and Staph. aureu
CONTRAINDICATIONS
Seizures may occur when administered at very high doses and in the presence of renal impairment. Sodium content should be considered when treating patients requiring salt restrictions (4.5 mEq (103.6 mg) of sodium per gram of ticarcillin/clavulanate).
ADVERSE EFFECTS
Eosinophilia. Hyperbilirubinemia. Elevations in ALT, AST, BUN, and serum creatinine. Hypernatremia may be exacerbated in ELBW patients.
ADMINISTRATION
Dilute in NS, D5W, or LR to a final concentration of 10 to 100 mg/mL and administer IV over 30 minutes.
MONITORING
Serum concentrations are not routinely monitored. Assess renal function prior to therapy. Measure serum sodium concentrations and hepatic transaminases periodically. Observe IV site for signs of extravasation.