NEODOSE

INDICATIONS

Skeletal muscle relaxation/paralysis in infants requiring mechanical ventilation. Proposed desirable effects are improved oxygenation/ ventilation, reduced barotrauma, and reduced fluctuations in cerebral blood flow.

ADVERSE EFFECTS

• Hypoxemia may occur because of inadequate mechanical ventilation and deterioration in pulmonary mechanics.
• Tachycardia and blood pressure changes (both hypotension and hypertension) occur frequently.
• Increased salivation.

ADMINISTRATION

• Must be accompanied by adequate analgesia and/or sedation.
• Administer IV push over 5 to 10 seconds. Has also been administered by continuous infusion. Concentrations are 1 to 2 mg/mL. May also be diluted to 0.5 mg/mL.

BLACK BOX WARNING

According to the manufacturer’s BLACK BOX WARNING, pancuronium should be administered by adequately trained individuals familiar with its actions, characteristics, and hazards.

MONITORING

Monitor vital signs frequently, blood pressure continuously. Use some form of eye lubrication.