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Infant Data
Results
MEDICAL INFORMATIONS
INDICATIONS
- Acute severe hypertension: . Nicardipine reduced blood pressure in neonatal patients experiencing hypertension while on extracorporeal membrane oxygenation (ECMO) without hypotensive episodes in a retrospective review of 8 neonates (median gestational age, 36.5 weeks; interquartile range, 35.3 to 38 weeks). The mean starting dose was 0.52 (+/- 0.22) mcg/kg/min and titrated to a maximum rate of 1.1 (+/- 0.85) mcg/kg/min (range, 0.3 to 3 mcg/kg/min) for a median duration of 51 hours (range, 4 to 227 hours)
CONTRAINDICATION
- Contraindicated in patients with advanced aortic stenosis.
ADVERSE EFFECTS
No adverse effects have been reported in neonates (small numbers). Hypotension andtachycardia are dose-dependent in adults. Headache, nausea, and vomiting were the other common effects reported.
ADMINISTRATION
- Intravenous:
- Dilute prior to administration to a concentration of 0.1 mg/mL or use premixed solution (0.1 mg/mL; 200 mL).
- Administer by a central line or large peripheral vein.
- There are literature reports of higher concentrations being used (0.5 mg/mL) in children without significant problems, except for superficial phlebitis.
MONITORING
Continuous monitoring of blood pressure, heart rate and rhythm during initiation of therapy, and frequently thereafter. Observe IV site for signs of irritation.