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Infant Data
Results
MEDICAL INFORMATIONS
INDICATIONS
Treatment of hypoglycemia refractory to intravenous dextrose infusions, or when dextrose infusion is unavailable, or in cases of documented glucagon deficiency.
CONTRAINDICATIONS
- Pheochromocytoma
- Insulinoma
- Hypersensitivity to lactose
PRECAUTIONS
- Concomitant Use:
- Use with anticholinergic drugs is not recommended.
- Dermatologic:
- Necrolytic migratory erythema has been reported with continuous glucagon infusion; discontinuation may be necessary. Consider risks versus benefits of continuous infusion therapy if necrolytic migratory erythema occurs.
- Endocrine & Metabolic:
- Inadequate reversal of hypoglycemia due to low levels of releasable glucose in the liver may occur in patients with adrenal insufficiency, chronic hypoglycemia, prolonged fasting, or starvation.
- Not recommended in patients with suspected insulinoma.
- Increase in blood glucose may occur initially in patients with insulinoma, however, exaggerated insulin release may also occur; treat symptoms of hypoglycemia with oral or IV glucose.
- Use caution in patients with suspected glucagonoma.
- Endoscopic or radiographic procedures:
- Use with caution when used as an adjunct to procedures designed to prohibit gastrointestinal motility in patients with known cardiac disease.
- Immunologic:
- Allergic reactions (eg, generalized rash, hypotension, or anaphylactic shock with breathing difficulties) may occur; generally occurred in association with endoscopic examination during which patients often received other agents including contrast media and local anesthetics.
ADVERSE EFFECTS
Nausea and vomiting, tachycardia, and ileus. Hyponatremia and thrombocytopenia have also been reported.
ADMINISTRATION
May administer subQ, IM, or IV push. Should not be used at concentrations greater than 1 mg/mL; use 1 mL of diluent provided or Sterile Water for Injection (GlucaGen®). For continuous infusion, glucagon in 10% dextrose has been used . There are no stability or concentration data available for glucagon in 10% dextrose.
MONITORING
Follow blood glucose concentration closely. Watch for rebound hypoglycemia. Rise in blood glucose will last approximately 2 hours.