Infant Data
Results
INDICATIONS
Antifungal agent used in combination with amphotericin B or fluconazole for treatment of infections caused by Candida, Cryptococcus, and other sensitive fungi.
ADVERSE EFFECTS
Toxicities are related to serum concentration above 100 mcg/mL, and are usually reversible if the drug is stopped or the dose is reduced. Fatal bone marrow depression (related to fluorouracil production), hepatitis, severe diarrhea, rash. Amphotericin B may increase toxicity by decreasing renal excretion.
BLACK BOX WARNING
According to the manufacturer’s BLACK BOX WARNINGextreme caution is recommended in patients with impaired renal function. Close monitoring of hematologic, renal, and hepatic status of all patients is essential.
MONITORING
Desired peak serum concentration ranges from 50 to 80 mcg/mL. Assess renal function. Follow GI status closely. Twice-weekly CBC and platelet counts. Periodic AST, ALT.