Infant Data
Results
INDICATIONS
Treatment of moderate to severe hypertension. Afterload reduction in patients with congestive heart failure.
CONTRAINDICATIONS/PRECAUTIONS
Use with extreme caution in patients with impaired renal function: oliguria and increased serum creatinine occur frequently.
ADVERSE EFFECTS
Hypotension occurs primarily in patients who are volume-depleted. Hyperkalemia occurs primarily in patients receiving potassium-sparing diuretics or potassium supplements. Cough has been reported frequently in adults. The CrCl significantly decreased in preterm and term neonates with cardiovascular disease after initiation of ACEIs (captopril or enalapril) in a retrospective review (n=206). The body surface area was less than 0.33 m2 for all neonates.
ADMINISTRATION
Administer over 5 minutes undiluted, or diluted to a concentration as low as 0.025 mg/mL.
MONITORING
Frequent assessment of blood pressure, particularly after the first dose. Periodic assessment of renal function and serum potassium.