Infant Data
Results
INDICATIONS
- Hypoperfusion and Hypotension: Treatment of hypoperfusion and hypotension, specially if related to myocardial dysfunction.
- Severe Sepsis and Septic Shock:
ADVERSE EFFECTS
May cause hypotension if patient is hypovolemic. Volume loading is recommended before starting DOBUTamine therapy. Tachycardia occurs at high dosage. Arrhythmias, hypertension, and cutaneous vasodilation. Increases myocardial oxygen consumption. Tissue ischemia occurs with infiltration.
ADMINISTRATION
May administer by IV or IO route as a continuous infusion. Avoid bolus administration of the drug. Infusion into a large vein is preferred to minimize risk of tissue extravasation. Vials must be diluted prior to use in compatible diluent up to a concentration of 4000 mcg/mL. Solutions containing DOBUTamine may exhibit a pink color which will increase with time due to oxidation of the drug. There is no significant loss of potency over 24 hours. The recommended concentration in neonates is 2000 mcg/mL.
Solution Preparation Calculations
MONITORING
Continuous heart rate and intra-arterial blood pressure monitoring preferable. Observe IV site for signs of extravasation. For a full-term newborn, the target heart rate and perfusion pressure (mean arterial pressure minus central venous pressure) are 110 to 160 beats/min and 55 mm Hg, respectively