NEODOSE

INDICATIONS

• Bronchopulmonary dysplasia (BPD): May improve pulmonary function in patients with BPD; typically a thiazide and spironolactone are used together. In oxygen-dependent infants who were on ventilator support over thirty days (n=43), chlorothiazide (40 mg/kg/day orally in 2 divided doses) in combination with spironolactone (4 mg/kg/day orally in 2 divided doses) until supplemental oxygen was discontinued was associated with improved pulmonary function and decreased fractional oxygen requirement, but was not associated with a decrease in duration of oxygen requirement when compared with placebo. Thiazide diuretics may be appropriate for improving lung mechanics in ventilator-dependent preterm infants greater than 3 weeks of age.
• Diabetes insipidus: Thiazide diuretics are recommended to treat central and/or nephrogenic diabetes insipidus.
• Edema and Hypertension: Diuretic used in treating both mild to moderate edema and mild to moderate hypertension. Effects increased when used in combination with furosemide or spironolactone.
• Heart Failure: In neonates with pulmonary hypertension, supportive care with diuretics may be used cautiously for signs of right-sided heart failure.

ADVERSE EFFECTS

Hypokalemia and other electrolyte abnormalities. Hyperglycemia. Hyperuricemia. Do not use in patients with significant impairment of renal or hepatic function.

ADMINISTRATION

For IV intermittent infusion, dilute to a concentration of 20 to 25 mg/mL in compatible solution and infuse over 15 to 60 minutes. In the preparation and administration of injections, the National Institute for Occupational Safety and Health (NIOSH) recommends the use of double gloves and a protective gown. Prepare in a biological safety cabinet or a compounding aseptic containment isolator; eye/face and respiratory protection may be needed. Prepare compounds in a closed system drug transfer device. During administration, if there is a potential that the substance could splash or if the patient may resist, use eye/face protection. Administer certain dosage forms via a closed system drug transfer device.

MONITORING

Serum electrolytes, calcium, phosphorus, and glucose; urine output and blood pressure.