Infant Data
PMA= gestational age plus postnatal age
Results
INDICATIONS
Treatment of neonatal sepsis caused by susceptible gram-negative organisms (e.g. E coli, H influenzae, Klebsiella, Pseudomonas, and Serratia). Generally used in combination with ampicillin (empirical treatment of sepsis) or an aminoglycoside (for synergism against Pseudomonas and Enterobacteriaceae).
ADVERSE EFFECTSAztreonam contains 780 mg L-arginine per gram of drug (23.4 mg/kg body weight per dose). Adequate amounts of glucose must be provided to prevent hypoglycemia. Side effects are rare but include eosinophilia, elevation of serum transaminases, and phlebitis at the injection site.
ADMINISTRATION
- Intravenous: Give IV push over 3 to 5 minutes, or IV infusion over 20 to 60 minutes at a final concentration not to exceed 20 mg/mL.
- Intramuscular: For IM administration, concentrations range from 66 mg/mL to 333 mg/mL.
MONITORING
Check serum glucose one hour after administration. Measuring serum concentration is not usually necessary. Periodic CBC, AST, ALT.