NEODOSE

INDICATIONS

• Anthrax, Treatment and Prophylaxis:

• Urinary Tract Infection (UTI), Prophylaxis: Some experts recommend amoxicillin prophylaxis starting at birth and continuing until vesicoureteral reflux (VUR) is ruled out in neonates with hydronephrosis, though there are no studies in neonates to support prophylaxis. The use of prophylactic antibiotics for VUR is controversial. When no prophylactic antibiotics were administered, the 2-year rate for recurrent UTI in children (2 months to 71 months of age) was 25.4% and 17.3% with VUR and without VUR, respectively . In children 2 months to 71 months with vesicoureteral reflux, trimethoprim sulfamethoxazole prophylaxis reduced the risk of infections but did not reduce renal scarring at 2 years ; therefore, evidence for routine use of prophylaxis is not established.

FDA APPROVED INDICATION

For infection caused by β – lactamase – negative organisms only

• Ear, nose and throat infections: Ear, nose and throat infections caused by Streptococcus species(alpha – and betahemolytic strains only), S pneumoniae, Staphylococcus species, or Haemophilus influenzae.For individuals without a penicillin allergy, penicillin o amoxicillin are the agents of choice for the treatment of group A streptococcal pharyngitis.
• Genitourinary tract infections: Genitourinary trac infections caused by Escherichia coli, Proteus mirabilis, or Enterococcus faecalis.
• Skin and skin structure infections: caused by Streptococcus species(alpha – and betahemolytic strains only), Staphylococcus species, or E coli.
• Lower respiratory tract infections: caused by Streptococcus species(alpha – and betahemolytic strains only), S pneumoniae, Staphylococcus species, or H influenza.

PRECAUTIONS

• Endocrine & Metabolic:
  • False positive readings for glucose urine tests may occur with Clinitest(R), Benedict Solution, or Fehling Solution. Use enzymatic glucose oxidase reactiontype tests.
• Gastrointestinal:
  • Clostridium difficile-associated diarrhea, including mild diarrhea to fatal colitis, has been reported and may occur over 2 months from last dose. Ongoing antibiotic use not directed against c difficile may need to be discontinued.
• Immunologic:
  • Severe anaphylactic reactions, including fatalities, have been reported, especially in patients with a history of penicillin hypersensitivity or sensitivity to multiple allergens.
• Mononucleosis:
  • Avoid use due to a high risk of developing an erythematous skin rash.
• Renal:
  • Severe renal impairment (ie, GFR less than 30 mL/min) or hemodialysis; dose adjustment recommended.

ADVERSE EFFECTS

Common adverse effects include rash, diarrhea, nausea, and vomiting;

ADMINISTRATION

Suspension:

Shake well before measuring the dose; place on tongue for swallowing; may mix the dose with formula, milk, fruit juice, water, ginger ale, or cold drinks; after mixing, administer immediately and completely. May also dissolve amoxicillin powder in breast milk to a concentration of 50 mg/mL.