NEODOSE

INDICATIONS

• Treatment of neonatal apnea, including post-extubation, post-anesthesia, and prostaglandin E1-induced.
• Bronchodilator.
• May improve respiratory function.

ADVERSE EFFECTS

GI irritation. Hyperglycemia. CNS irritability and sleeplessness. May be associated with renal calcifications when used concurrently with furosemide and/or dexamethasone. Signs of toxicity: Sinus tachycardia, failure to gain weight, vomiting, jitteriness, hyperreflexia, and seizures. Treatment of Serious Theophylline Toxicity: Activated charcoal, 1 g/kg as a slurry by gavage tube every 2 to 4 hours. Avoid sorbitol-containing preparations: They may cause osmotic diarrhea.

ADMINISTRATION

Intravenous bolus over 30 to 60 minutes . May give as 25-mg/mL concentration or further dilute to as low as 1 mg/mL for continuous infusion.

MONITORING

Monitor heart rate and check blood glucose periodically with reagent strips. Assess for agitation and feeding intolerance. Consider withholding next dose if heart rate is greater than 180 beats per minute. When indicated by lack of efficacy or clinical signs of toxicity, serum trough concentration should be obtained.

Therapeutic ranges are:

1) Apnea of prematurity: 7 to 12 mcg/mL. 2) Bronchospasm: 10 to 20 mcg / mL(older infants with bronchospasm may need these higher levels because of increased protein binding).