CALCUTIONS AREA
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Infant Data
Results
MEDICAL INFORMATIONS
INDICATIONS
- Neonatal transient myasthenia gravis.
- Neonatal persistent (congenital) myasthenia gravis.
FDA APPROVED INDICATION
Reversal of neuromuscular blocking agents
CONTRAINDICATION
Contraindicated in the presence of intestinal or urinary obstruction or in the presence of peritonitis.
CONTRAINDICATION
- Use cautiously in patients with bronchospasm, cardiac arrhythmia, hypotension, or bradycardia
- Large doses may cause neuromuscular dysfunction in patients with minimal blockade; dose reduction recommended if recovery from neuromuscular blockade is nearly complete .
ADVERSE EFFECTS
Adverse effects include muscle weakness, tremors, bradycardia, hypotension, respiratory depression, bronchospasm, diarrhea, and excessive salivation.
ADMINISTRATION
Administer IV over at least 1 minute. Give with atropine or glycopyrrolate to prevent possible bradycardia, increased salivation, and hyperperistalsis . For myasthenia gravis diagnosis, test dose is given IM .
MONITORING
- Monitor respiratory and cardiovascular status closely .
- Train-of-four monitoring should used to evaluate recovery of neuromuscular blockade